Newsbureau is a high-traffic, fully custom Content Management site built on ASP.NET 1.1 back in the days before DotNetNuke (or any other CMSs, for that matter!). It could use a facelift, but it's still chugging along.
From the newsbureau website:
Newsbureau helps journalists and business leaders share relevant information faster and easier. Newsbureau is an intuitive, easy-to-use service that creates productive, personal relationships between business leaders and journalists who cover a variety of disciplines.
This unique, interactive Canadian media resource leads the industry with its forward technology and savvy personal service. Newsbureau satisfies client and journalist needs for timely information and trustworthy connections.
Through fruitful partnerships, newsbureau serves everyone from small business owners to CEOs of large corporations; from freelancers to top editors and directors in all mediums.
The live site can be viewed here.